FA Cup holders Arsenal will host West Ham United on 8th August to kick off their Barclays Premier League 2015/16 campaign which will conclude with a match against Aston Villa next May.
The Gunners finished amongst the top four on league table just 12 points behind reigning champions Chelsea but ended the campaign on a high note with a resounding 4-0 victory against Aston Villa at Wembley to retain the FA Cup.
| Date | Time | Opponent | Venue | Status |
| Sun. 9 | 12:30 GMT | West Ham United | Emirates Stadium | Home |
| Sun. 16 | 12:30 GMT | Crystal Palace | Selhurst Park | Away |
| Mon. 24 | 19:00 GMT | Liverpool | Emirates Stadium | Home |
| Sat. 29 | 11:45 GMT | Newcastle United | St. James’ Park | Away |
| September 2015 | ||||
| Date | Time | Opponent | Venue | Status |
| Sat. 12 | 14:00 GMT | Stoke City | Emirates Stadium | Home |
| Sat. 19 | 11:45 GMT | Chelsea | Stamford Bridge | Away |
| Sat. 26 | 14:00 GMT | Leicester City | King Power Stadium | Away |
| October 2015 | ||||
| Date | Time | Opponent | Venue | Status |
| Sun. 4 | 15:00 GMT | Manchester United | Emirates Stadium | Home |
| Sat. 17 | 16:30 GMT | Watford | Vicarage Road | Away |
| Sat. 24 | 16:30 GMT | Everton | Emirates Stadium | Home |
| Sat. 31 | 15:00 GMT | Swansea City | Liberty Stadium | Away |
| November 2015 | ||||
| Date | Time | Opponent | Venue | Status |
| Sun. 8 | 16:00 GMT | Tottenham Hotspur | Emirates Stadium | Home |
| Sat. 21 | 15:00 GMT | West Bromwich Albion | The Hawthorns | Away |
| Sun. 29 | 16:15 GMT | Norwich City | Carrow Road | Away |
| December 2015 | ||||
| Date | Time | Opponent | Venue | Status |
| Sat. 5 | 15:00 GMT | Sunderland | Emirates Stadium | Home |
| Sat. 12 | 15:00 GMT | Aston Villa | Villa Park | Away |
| Sat. 19 | 15:00 GMT | Manchester City | Emirates Stadium | Home |
| Sat. 26 | 15:00 GMT | Southampton | St. Mary’s Stadium | Away |
| Mon. 28 | 15:00 GMT | Bournemouth | Emirates Stadium | Home |
| January 2016 | ||||
| Date | Time | Opponent | Venue | Status |
| Sat. 2 | 15:00 GMT | Newcastle United | Emirates Stadium | Home |
| Tue. 12 | 20:00 GMT | Liverpool | Anfield | Away |
| Sat. 16 | 15:00 GMT | Stoke City | Britannia Stadium | Away |
| Sat. 23 | 15:00 GMT | Chelsea | Emirates Stadium | Home |
| February 2016 | ||||
| Date | Time | Opponent | Venue | Status |
| Tue. 2 | 19:45 GMT | Southampton | Emirates Stadium | Home |
| Sat. 6 | 15:00 GMT | Bournemouth | Vitality Stadium | Away |
| Sat. 13 | 15:00 GMT | Leicester City | Emirates Stadium | Home |
| Sat. 27 | 15:00 GMT | Manchester United | Old Trafford | Away |
| March 2016 | ||||
| Date | Time | Opponent | Venue | Status |
| Tue. 1 | 19:45 GMT | Swansea City | Emirates Stadium | Home |
| Sat. 5 | 15:00 GMT | Tottenham Hotspur | White Hart Lane | Away |
| Sat. 12 | 15:00 GMT | West Bromwich Albion | Emirates Stadium | Home |
| Sat. 19 | 15:00 GMT | Everton | Goodison Park | Away |
| April 2016 | ||||
| Date | Time | Opponent | Venue | Status |
| Sat. 2 | 14:00 GMT | Watford | Emirates Stadium | Home |
| Sat. 9 | 14:00 GMT | West Ham United | Upton Park | Away |
| Sat. 16 | 14:00 GMT | Crystal Palace | Emirates Stadium | Home |
| Sat. 23 | 14:00 GMT | Sunderland | Stadium Of Light | Away |
| Sat. 30 | 14:00 GMT | Norwich City | Emirates Stadium | Home |
| May 2016 | ||||
| Date | Time | Opponent | Venue | Status |
| Sat. 7 | 14:00 GMT | Manchester City | Etihad Stadium | Away |
| Sun. 15 | 14:00 GMT | Aston Villa | Emirates Stadium | Home |
