Mauricio Pochettino has made several changes from the side that lost to Arsenal in the Capital One Cup with Kyle Walker, Toby Alderweireld, Jan Vertonghen and Ben Davies all coming in to the defence.
Manuel Pellegrini has surprisingly made just one change to his side that beat Sunderland in midweek with the likes of Joe Hart, Vincent Kompany, Samir Nasri and Pablo Zabaleta all left on the bench.
Lloris, Walker, Alderweireld, Vertonghen, Davies; Alli, Dier; Eriksen, Son, Lamela; Kane
Subs: Vorm, Rose, Trippier, Carroll, Chadli, Townsend, Clinton
Caballero, Sagna, Demichelis, Otamendi, Kolarov, Fernando, Fernandinho, De Bruyne, Sterling, Toure, Aguero
Subs: Hart, Kompany, Zabaleta, Nasri, Navas, Roberts, Barker